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Synthesis of Tetracyclic Tetrahydro‐β‐carbolines by Acid‐Promoted One‐Pot Sequential Formation of C−C and C−N Bonds
Author(s) -
Nagaraju Vemu,
Purnachander Dalovai,
Goutham Kommuru,
Suresh Surisetti,
Sridhar Balasubramanian,
Karunakar Galla V.
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600349
Subject(s) - chemistry , reaction conditions , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis
An efficient synthetic protocol was developed for the formation of tetracyclic tetrahydro‐β‐carbolines using a p ‐toluenesulfonic acid‐mediated reaction of β‐enaminones and acetylenedicarboxylates. Highly functionalised tetracyclic tetrahydro‐β‐carboline derivatives were synthesised under one‐pot reaction conditions, in which two C−C and one C−N bonds were sequentially formed.