Synthesis of Tetracyclic Tetrahydro‐β‐carbolines by Acid‐Promoted One‐Pot Sequential Formation of C−C and C−N Bonds | Zendy

Nagaraju Vemu | Zendy; Purnachander Dalovai | Zendy; Goutham Kommuru | Zendy; Suresh Surisetti | Zendy; Sridhar Balasubramanian | Zendy; Karunakar Galla V. | Zendy

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Synthesis of Tetracyclic Tetrahydro‐β‐carbolines by Acid‐Promoted One‐Pot Sequential Formation of C−C and C−N Bonds

Author(s) -

Nagaraju Vemu,

Purnachander Dalovai,

Goutham Kommuru,

Suresh Surisetti,

Sridhar Balasubramanian,

Karunakar Galla V.

Publication year - 2016

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201600349

Subject(s) - chemistry , reaction conditions , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis

An efficient synthetic protocol was developed for the formation of tetracyclic tetrahydro‐β‐carbolines using a p ‐toluenesulfonic acid‐mediated reaction of β‐enaminones and acetylenedicarboxylates. Highly functionalised tetracyclic tetrahydro‐β‐carboline derivatives were synthesised under one‐pot reaction conditions, in which two C−C and one C−N bonds were sequentially formed.

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