Premium
A Formal Synthesis of Komaroviquinone: Use of a Pt‐Catalyzed Hydrative Cyclization Reaction
Author(s) -
Oh Chang Ho,
Piao Lanhua,
Jung Jaemun,
Kim Jaewoong
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600340
Subject(s) - chemistry , formal synthesis , catalysis , combinatorial chemistry , convergent synthesis , organic chemistry
A formal synthesis of komaroviquinone has been accomplished by utilizing the Pt‐catalyzed hydrative cyclization of an enynal that was easily prepared in a convergent manner. The Pt‐catalyzed hydrative cyclization reaction afforded the corresponding tricyclic product, which was utilized in the synthesis of a known precursor that led to the formation of komaroviquinone through an additional four‐step synthesis.