Premium
Redox‐Neutral C1 Functionalization of Unprotected Tetrahydroisoquinolines with Diazo Carbonyl Compounds
Author(s) -
Huang Jun,
Li Linyong,
Xiao Tiebo,
Mao Zongwan,
Zhou Lei
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600338
Subject(s) - diazo , chemistry , surface modification , regioselectivity , redox , organic chemistry , combinatorial chemistry , catalysis
Abstract A silver or acid‐mediated three‐component reaction of tetrahydroisoquinolines, benzaldehydes, and diazo compounds has been developed. The reaction provides a novel route to β‐amino‐α‐diazo compounds through redox‐neutral C1 functionalization of unprotected THIQs with diazo carbonyl motifs with high regioselectivity.