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Palladium‐Catalyzed Diverse mono ‐Acyloxylation of 5‐Alkyl‐4‐aryl‐thiazole‐2‐carboxylates
Author(s) -
Yu KunKun,
Guo Ying,
Hu YaHua,
Xu Zhi,
Liu HongWei,
Liao DaoHua,
Ji YaFei
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600304
Subject(s) - chemistry , aryl , thiazole , catalysis , palladium , alkyl , combinatorial chemistry , selectivity , organic chemistry , surface modification
The palladium‐catalyzed oxidative acyloxylation of 5‐alkyl‐4‐aryl‐thiazole‐2‐carboxylates via a direct ortho ‐Csp 2 −H bond activation has been described with a newly reported radical mechanism. Based on the late‐stage functionalization of the highly substituted thiazoles, the reaction delivered multifarious valuable acyloxylated products with moderate‐to‐excellent yields. The transformation affords highly functionalized substrates, has broad scope of carboxylic acid coupling partners, excellent site‐selectivity, rapid reaction rates, simple operation and mild conditions. The diverse acyloxylation reaction allows rapid access to a plethora of mono ‐acyloxylated products from the functionalized thiazoles.