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Cover Picture: Copper‐Catalyzed Double Decarboxylative Coupling Reactions of Alkynyl Carboxylic Acid and Glyoxylic Acid: Synthesis of Propargyl Amines and Imidazopyridines (Asian J. Org. Chem. 6/2016)
Author(s) -
Choi Jinseop,
Lim Jeongah,
Irudayanathan Francis Mariaraj,
Kim HanSung,
Park Jaerim,
Yu Su Been,
Jang Yuna,
Raja Gabriel Charles Edwin,
Nam Kye Chun,
Kim Jimin,
Lee Sunwoo
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600236
Subject(s) - chemistry , propargyl , copper , catalysis , glyoxylic acid , organic chemistry , decarboxylation , cover (algebra) , coupling (piping) , medicinal chemistry , mechanical engineering , engineering
A double decarboxylative coupling reaction was developed. Alkynyl carboxylic acids, glyoxylic acid, and amines were reacted in the presence of a copper catalyst to afford the corresponding propargyl amines in good yields. It was found that the alkynyl carboxylic acid showed similar reactivity to a terminal alkyne, and the reactivity of glyoxylic acid was almost identical to that of an aldehyde in this coupling reaction. More information can be found in the full paper by S. Lee and co‐workers on page 770 in Issue 6, 2016 (DOI: 10.1002/ajoc.201600109).