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Total Synthesis of Marine Natural Products: Cephalosporolides
Author(s) -
Halle Mahesh B.,
Fernandes Rodney A.
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600208
Subject(s) - chemistry , marine toxin , total synthesis , algae , stereochemistry , stereoselectivity , sponge , molecule , computational biology , combinatorial chemistry , ecology , organic chemistry , botany , biology , biochemistry , catalysis , toxin
Abstract Marine‐derived species, in particular, fungi, algae, sponges, and coelenterates are fertile grounds for the discovery of biologically and pharmacologically potent compounds. These molecules are structurally unique and possess a wide range of pharmacological activities. The rigid spiroacetal framework, that is, tetrahydro‐spirofurofuranones is present in cephalosporolides E, F, H, and I, while the macrolactone structure is exemplified by cephalosporolides B, C, D, G, and J. These marine‐derived molecular architectures are appealing to the synthetic community for their stereoselective synthesis. The present review represents a comprehensive overview of all the reported syntheses of these marine‐derived molecules.