Premium
Ugi‐type Multicomponent Reaction of Nitrile Imines, Isocyanides, and Isocyanates: Effective Synthesis of 1,2,4‐Triazinedione Derivatives
Author(s) -
Soeta Takahiro,
Takashita Suguru,
Sakata Yoko,
Ukaji Yutaka
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600191
Subject(s) - chemistry , isocyanide , nitrile , isocyanate , imine , ugi reaction , organic chemistry , combinatorial chemistry , catalysis , polyurethane
We have developed a Ugi‐type multicomponent reaction, in which a nitrile imine, an isocyanide, and an isocyanate reacted to give the corresponding 1,2,4‐triazinedione derivatives in good‐to‐high yields. This reaction is one of the few examples of isocyanide‐based multicomponent reactions using an isocyanate in place of a carboxylic acid. A wide range of nitrile imines, isocyanides, and isocyanates were found to be applicable to the reaction.