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Fluorofuroxans: Synthesis and Application as Photoinduced Nitric Oxide Donors
Author(s) -
Ando Akihiro,
Matsubara Ryosuke,
Takazawa Saori,
Shimada Toshiyuki,
Hayashi Masahiko
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600149
Subject(s) - nitric oxide , chemistry , thiol , oxide , photochemistry , organic chemistry
The synthesis of 3‐ and 4‐fluorofuroxans is reported for the first time. Under photoirradiation and physiological conditions, 4‐fluorofuroxans with weaker nitric oxide‐releasing ability are converted into 3‐fluorofuroxans, which show remarkable thiol‐mediated nitric oxide‐releasing properties, thereby suggesting that 4‐fluorofuroxans are potent photoinduced nitric oxide donors.