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Oxidative Remote C−H Trifluoromethylation of Quinolineamides on the C5 Position with Iodobenzene Diacetate as the Oxidizing Agent
Author(s) -
Wu Zhaoyang,
He Yongqin,
Ma Chaowei,
Zhou Xiaoqiang,
Liu Xingxing,
Li Yamin,
Hu Ting,
Wen Ping,
Huang Guosheng
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600128
Subject(s) - trifluoromethylation , oxidizing agent , iodobenzene , chemistry , reagent , combinatorial chemistry , hypervalent molecule , oxidative phosphorylation , organic chemistry , catalysis , trifluoromethyl , biochemistry , alkyl
A facile, metal‐free protocol has been developed for the remote trifluoromethylation of 8‐aminoquinoline scaffolds on the C5 position, which is difficult to functionalize. In this method, 8‐aminoquinolineamides reacted with an inexpensive and commercially available CF 3 source (Langlois reagent) to give a wide range of trifluoromethylated aminoquinolineamides.