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Rapid and Efficient Cascade Synthesis of 2‐Amino‐4(3 H )‐quinazolinones over an In Situ‐Generated Heterogeneous CuCO 3 –K 2 CO 3 Nanocomposite
Author(s) -
Thakur Maheshwar S.,
Nayal Onkar S.,
Bhatt Vinod,
Sharma Sushila,
Kumar Neeraj
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600113
Subject(s) - chemistry , cascade , in situ , combinatorial chemistry , stereochemistry , nanotechnology , computational chemistry , organic chemistry , chromatography , materials science
A green, recyclable, in situ‐generated, heterogeneous CuCO 3 –K 2 CO 3 nanocomposite‐catalysed cascade reaction between 2‐halobenzoic acids and guanidines is described for the synthesis of 2‐amino‐4(3 H )‐quinazolinones. The reaction is rapid and proceeds efficiently in air without the addition of a ligand or additive. This protocol is equally applicable to amidines for the synthesis of 2‐alkyl‐ and 2‐phenyl‐4(3 H )‐quinazolinones.