Rapid and Efficient Cascade Synthesis of 2‐Amino‐4(3  H )‐quinazolinones over an In Situ‐Generated Heterogeneous CuCO 3 –K 2 CO 3  Nanocomposite | Zendy

Thakur Maheshwar S. | Zendy; Nayal Onkar S. | Zendy; Bhatt Vinod | Zendy; Sharma Sushila | Zendy; Kumar Neeraj | Zendy

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Rapid and Efficient Cascade Synthesis of 2‐Amino‐4(3 H )‐quinazolinones over an In Situ‐Generated Heterogeneous CuCO 3 –K 2 CO 3 Nanocomposite

Author(s) -

Thakur Maheshwar S.,

Nayal Onkar S.,

Bhatt Vinod,

Sharma Sushila,

Kumar Neeraj

Publication year - 2016

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201600113

Subject(s) - chemistry , cascade , in situ , combinatorial chemistry , stereochemistry , nanotechnology , computational chemistry , organic chemistry , chromatography , materials science

A green, recyclable, in situ‐generated, heterogeneous CuCO 3 –K 2 CO 3 nanocomposite‐catalysed cascade reaction between 2‐halobenzoic acids and guanidines is described for the synthesis of 2‐amino‐4(3 H )‐quinazolinones. The reaction is rapid and proceeds efficiently in air without the addition of a ligand or additive. This protocol is equally applicable to amidines for the synthesis of 2‐alkyl‐ and 2‐phenyl‐4(3 H )‐quinazolinones.

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