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Solvent‐Free Pot‐, Atom‐ and Step‐Economic Synthesis of Novel Benzo[ d ]thiazole‐[1,3]‐thiazine Hybrids in a One‐Pot Reaction
Author(s) -
Wadhwa Preeti,
Kaur Tanpreet,
Sharma Anuj
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600098
Subject(s) - thiazole , thiazine , chemistry , microwave irradiation , combinatorial chemistry , catalysis , solvent , green chemistry , atom economy , organic chemistry , reaction mechanism
The first catalyst‐ and solvent‐free synthesis of novel benzo[ d ]thiazole‐[1,3]‐thiazine hybrids from benzo[ d ]thiazol‐2‐amines, isothiocyanates and dialkyl acetylenedicarboxylates with no more than 30 min of microwave irradiation is described. Moreover, the proposed strategy involves neither tedious workup nor column purification steps. This approach provides a diversity‐oriented route for the rapid assembly of benzo[ d ]thiazole‐[1,3]‐thiazine frameworks. Furthermore, the methodology has excellent green credentials, scoring well in a number of green metrics, hence showing this approach to be an ideal green and sustainable process.