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Cover Picture: Palladium‐Catalyzed Carbonylative Multicomponent Synthesis of Functionalized Benzimidazothiazoles (Asian J. Org. Chem. 4/2016)
Author(s) -
Veltri Lucia,
Grasso Giuseppe,
Rizzi Rosanna,
Mancuso Raffaella,
Gabriele Bartolo
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600097
Subject(s) - chemistry , isomerization , intramolecular force , palladium , catalysis , triple bond , conjugated system , carbonylation , amine gas treating , medicinal chemistry , combinatorial chemistry , organic chemistry , double bond , carbon monoxide , polymer
Functionalized benzimidazothiazoles were obtained in one step by a Pd‐catalyzed multicomponent carbonylative heterocyclization process, starting from 2‐prop‐2‐ynylsulfanyl‐3 H ‐benzimidazolium salts, CO, a secondary amine, and O 2 . The PdI 2 /KI‐catalyzed oxidative aminocarbonylation of the terminal triple bond was followed in situ by intramolecular conjugated addition and isomerization to give the final product in fair to good yields. More information can be found in the full paper by L. Veltri and B. Gabriele et al. on page 560 in Issue 4, 2016 (DOI: 10.1002/ajoc.201600042).