A Powerful Method for the Direct Arylation of Furans at a Sterically Congested C−H Bond | Zendy

Nishikata Takashi | Zendy; Yamane Yu | Zendy; Yamaguchi Yousui | Zendy; Ishikawa Shingo | Zendy

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A Powerful Method for the Direct Arylation of Furans at a Sterically Congested C−H Bond

Author(s) -

Nishikata Takashi,

Yamane Yu,

Yamaguchi Yousui,

Ishikawa Shingo

Publication year - 2016

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201600057

Subject(s) - steric effects , chemistry , catalysis , salt (chemistry) , medicinal chemistry , combinatorial chemistry , organic chemistry

The direct arylation of furans at a sterically congested C−H bond are accomplished. Although there are many methods for catalytic C−H arylation, direct C−H arylation at bulky reaction sites is one of the most problematic issues in this area. In this study, we found that a PdCl 2 ‐1,2‐bis(dicyclohexylphosphino)ethane (dcype) or PCy 3 and silver salt system enables arylations at a sterically congested C−H bonds to produce “highly congested” and “very congested” triarylfurans.

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