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A Powerful Method for the Direct Arylation of Furans at a Sterically Congested C−H Bond
Author(s) -
Nishikata Takashi,
Yamane Yu,
Yamaguchi Yousui,
Ishikawa Shingo
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600057
Subject(s) - steric effects , chemistry , catalysis , salt (chemistry) , medicinal chemistry , combinatorial chemistry , organic chemistry
Abstract The direct arylation of furans at a sterically congested C−H bond are accomplished. Although there are many methods for catalytic C−H arylation, direct C−H arylation at bulky reaction sites is one of the most problematic issues in this area. In this study, we found that a PdCl 2 ‐1,2‐bis(dicyclohexylphosphino)ethane (dcype) or PCy 3 and silver salt system enables arylations at a sterically congested C−H bonds to produce “highly congested” and “very congested” triarylfurans.