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Back Cover: Diastereoselective Synthesis of β‐Ether Derivatives of Artemisinin, an Antimalarial Drug: The Effect of Nitrile on Stereoselectivity (Asian J. Org. Chem. 2/2016)
Author(s) -
Chand Hemender R.,
Bhattacharya Asish K.
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600023
Subject(s) - artemisinin , chemistry , ether , nitrile , bridge (graph theory) , stereoselectivity , stereochemistry , total synthesis , combinatorial chemistry , malaria , plasmodium falciparum , organic chemistry , catalysis , immunology , biology , medicine
The Lakshman Jhula Bridge (a suspension bridge) on the holy river Ganga (Rishikesh in Uttarakhand state, India, well known as the land of temples) signifies the endoperoxide bridge functionality present in artemisinin, a unique structural feature responsible for its antimalarial activity. The bridge also represents an efficient way to narrow the gap for the cure of malaria through the synthesis of analogues, such as the β‐ether derivatives shown. More information can be found in the Full Paper by H. Chand and A. K. Bhattacharya on page 201 in Issue 2, 2016 (DOI: 10.1002/ajoc.201500415).