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Cover Picture: An Efficient One‐Pot Five‐Component Tandem Sequential Approach for the Synthesis of Pyranopyrazole Derivatives via Suzuki Coupling and Multicomponent Reaction (Asian J. Org. Chem. 5/2015)
Author(s) -
Lu Zhangxiu,
Xiao Jinlong,
Wang Dongyang,
Li Yiqun
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201590009
Subject(s) - chemistry , malononitrile , suzuki reaction , ethyl acetoacetate , combinatorial chemistry , tandem , phosphorescence , hydrazine (antidepressant) , coupling reaction , cascade reaction , organic chemistry , palladium , catalysis , materials science , physics , chromatography , quantum mechanics , composite material , fluorescence
Multicomponent reactions (MCRs) have emerged as a powerful tool for the construction of novel and complex molecular structures due to their advantages over conventional multistep synthesis. In their Full Paper on page 487 , Yiqun Li and co‐workers have developed a one‐pot, tandem, sequential, five component reaction (5CR) protocol for the synthesis of a wide range of biaryl‐substituted pyranopyrazole derivatives via Suzuki coupling of 4‐bromobenzaldehyde and phenylbronic acids followed by four‐component reaction of ethyl acetoacetate, malononitrile, and hydrazine hydrate without isolation and/or purification of intermediates.