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Cover Picture: Intracellular Reduction‐Responsive Sheddable Copolymer Micelles for Targeted Anticancer Drug Delivery (Asian J. Org. Chem. 3/2015)
Author(s) -
Zhang Yuanyuan,
Qu Qiuyu,
Li Menghuan,
Zhao Yanli
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201590004
Subject(s) - micelle , intracellular , chemistry , drug delivery , copolymer , flow cytometry , drug , confocal microscopy , biophysics , doxorubicin , cytoplasm , anticancer drug , targeted drug delivery , nanotechnology , biochemistry , polymer , microbiology and biotechnology , pharmacology , organic chemistry , materials science , biology , aqueous solution , genetics , chemotherapy
Intracellular, reduction‐responsive , copolymer micelles have been developed for targeted anticancer drug delivery by Yanli Zhao et al. In their Full paper on page 226 , they present copolymer micelles that show a promising potential for targeted anticancer applications. The anticancer drug doxorubicin is encapsulated into the micelles during the micellization of the polymer, and then released rapidly into the environment under the stimulus of an intracellular reducing agent. Flow cytometry and confocal laser scanning microscopy observations indicate that the drug is successfully released from the internalized micelles into the cytoplasm, inducing apoptosis and cell death.