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Cover Picture: Fast and Efficient Synthesis of Z ‐Enol‐γ‐Lactones through a Cycloisomerization Reaction of β‐Hydroxy‐γ‐Alkynoic Acids Catalyzed by Copper(I) under Microwave Heating in Water (Asian J. Org. Chem. 6/2015)
Author(s) -
LópezReyes Morelia E.,
Toscano R. Alfredo,
LópezCortés José G.,
AlvarezToledano Cecilio
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201580601
Subject(s) - cycloisomerization , enol , catalysis , chemistry , copper , transition metal , organic chemistry , combinatorial chemistry
The cycloisomerization reaction of γ‐alkynoic acids mediated by transition‐metal catalysts has become a successful strategy for accessing enol lactones during the past few years. In their Full Paper on page 545, Cecilio Alvarez‐Toledano and co‐workers developed a fast and efficient protocol for the regio and diastereoselective cycloisomerization of β‐hydroxy‐γ‐alkynoic acids, catalyzed by the inexpensive and air‐stable catalyst CuBr (5 mol%) in water under microwave heating. This method provides rapid access to a variety of highly functionalized Z ‐enol‐γ‐lactones in good yields under mild reaction conditions.