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Recent Developments in the Synthesis of Chiral Compounds with Quaternary Centers by Organocatalytic Cascade Reactions
Author(s) -
Tian Li,
Luo YongChun,
Hu XiuQin,
Xu PengFei
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500486
Subject(s) - stereocenter , enantioselective synthesis , quaternary carbon , chemistry , cascade , organocatalysis , quaternary , combinatorial chemistry , optically active , organic chemistry , catalysis , paleontology , chromatography , biology
Abstract Quaternary carbon stereocenters are present in a wide variety of organic compounds and drug molecules. Highly enantioselective construction of such quaternary carbon stereocenters has received considerable attention owing to the great challenges in their syntheses. With the development of asymmetric organocatalytic cascade reactions, several efficient methods for the construction of optically pure compounds with quaternary carbon centers have been developed. This focused review highlights the asymmetric synthesis of chiral compounds with quaternary centers through organocatalytic cascade reactions.