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Hendrickson‐Reagent‐Mediated Conversion of N ‐Boc Carbamates to Isocyanates: Applications for the Synthesis of 3,4‐Dihydroisoquinolin‐1‐ones and Ureas
Author(s) -
Cho Hyunkyung,
Lee Jeong Ok,
Hwang Soonho,
Seo Jae Hong,
Kim Sanghee
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500462
Subject(s) - chemistry , reagent , isocyanate , urea , organic chemistry , reaction conditions , combinatorial chemistry , catalysis , polyurethane
An efficient method for isocyanate formation from N ‐Boc carbamates was developed utilizing a Hendrickson “POP” reagent as a dehydrating agent. By using this reagent, isocyanates were formed preferentially from N ‐Boc carbamates over other carbamates. The reaction could be paired with successive reactions such as Friedel–Crafts‐type cyclization and urea formation.