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Palladium‐Catalyzed C−H Bond Ortho Acylation/Annulation with Toluene Derivatives
Author(s) -
Yang Lingyun,
Han Li,
Xu Bin,
Zhao Leilei,
Zhou Jinpei,
Zhang Huibin
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500417
Subject(s) - chemistry , annulation , palladium , benzamide , acylation , toluene , catalysis , organic chemistry , cascade , medicinal chemistry , combinatorial chemistry , chromatography
A palladium‐catalyzed cascade cross‐coupling of benzamide and toluene for the synthesis of 3‐hydroxyisoindolin‐1‐one is described. This method allows C−H bond ortho acylation/annulation with a Pd/TBHP system in an atom‐economical and environmentally friendly manner. In addition, a variety of substrates are well tolerated.