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Triphenylphosphine/Triethylamine‐Mediated Decarboxylation of α‐Oxocarboxylic Acids and Application in a One‐Pot Synthesis of Deuterated Aldehydes.
Author(s) -
Niu GuangHao,
Huang PeiRu,
Chuang Gary Jing
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500382
Subject(s) - decarboxylation , chemistry , triethylamine , aryl , deuterium , alkyl , triphenylphosphine , organic chemistry , combinatorial chemistry , catalysis , physics , quantum mechanics
A simple method for synthesizing aldehydes from α‐oxocarboxylic acids via decarboxylation in the presence of PPh 3 and Et 3 N is reported. The decarboxylation can be performed on a wide range of α‐oxocarboxylic acids; electron‐rich/electron‐deficient aryl, heteroaryl, as well as alkyl α‐oxocarboxylic acids. This method also provides a convenient procedure for the synthesis of deuterated aldehydes using D 2 O as deuterium source in a facile one‐pot process.