Triphenylphosphine/Triethylamine‐Mediated Decarboxylation of α‐Oxocarboxylic Acids and Application in a One‐Pot Synthesis of Deuterated Aldehydes. | Zendy

Niu GuangHao | Zendy; Huang PeiRu | Zendy; Chuang Gary Jing | Zendy

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Triphenylphosphine/Triethylamine‐Mediated Decarboxylation of α‐Oxocarboxylic Acids and Application in a One‐Pot Synthesis of Deuterated Aldehydes.

Author(s) -

Niu GuangHao,

Huang PeiRu,

Chuang Gary Jing

Publication year - 2016

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201500382

Subject(s) - decarboxylation , chemistry , triethylamine , aryl , deuterium , alkyl , triphenylphosphine , organic chemistry , combinatorial chemistry , catalysis , physics , quantum mechanics

A simple method for synthesizing aldehydes from α‐oxocarboxylic acids via decarboxylation in the presence of PPh 3 and Et 3 N is reported. The decarboxylation can be performed on a wide range of α‐oxocarboxylic acids; electron‐rich/electron‐deficient aryl, heteroaryl, as well as alkyl α‐oxocarboxylic acids. This method also provides a convenient procedure for the synthesis of deuterated aldehydes using D 2 O as deuterium source in a facile one‐pot process.

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