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Cover Picture: Regiochemistry‐Directed Syntheses of Polyhydroxylated Alkaloids from Chiral Aziridines (Asian J. Org. Chem. 12/2015)
Author(s) -
Eum Heesung,
Choi Jihye,
Cho CheonGyu,
Ha HyunJoon
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500380
Subject(s) - regioselectivity , chemistry , aziridine , pyrrolidine , piperidine , ring (chemistry) , molecule , stereochemistry , organic chemistry , combinatorial chemistry , catalysis
The syntheses of two different classes of compounds branched from a common synthetic intermediate were developed by Hyun‐Joon Ha and co‐workers. Two different regiochemical pathways of aziridine ring‐opening of 2‐(dihydroxylated‐alkyl)aziridines provide easy access to two diverse classes of compounds including a variety of pyrrolidine‐ and piperidine‐based polyhydroxylated natural products and their analogues. This strategy, so called “regiochemistry‐directed branches for 2‐substituted aziridines”, is applicable for the easy preparation of structurally diverse and biologically important molecules. More information can be found in the full paper by H.‐J. Ha et al. (DOI: 10.1002/ajoc.201500285).