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Facile Synthesis of 4‐(Trifluoromethyl)‐1 H ‐isochromenes from Alkynols
Author(s) -
Ji Xiao Yue,
Siyang Hai Xiao,
Liu Kai,
Jiao Jia Jun,
Liu Pei Nian
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500357
Subject(s) - trifluoromethyl , chemistry , reagent , electrophile , combinatorial chemistry , trifluoromethylation , organic chemistry , catalysis , alkyl
Isochromene derivatives are important structural motifs found in various biologically active compounds as well as important natural products. A method to generate CF 3 ‐containing isochromene derivatives has been developed, which gives moderate to good yields by using Togni's reagent as the trifluoromethyl source. The key step involves alkynol cyclization and subsequent trapping by a reactive electrophilic trifluoromethyl species generated in situ from Togni's reagent.