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A Four‐Component Domino Reaction: An Eco‐Compatible Access to Diversified Imidazo[2,1‐ b ][1,3]thiazin‐5‐ones
Author(s) -
Kaur Tanpreet,
Wadhwa Preeti,
Sharma Anuj
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500344
Subject(s) - chemistry , domino , thiourea , reagent , aryl , combinatorial chemistry , alkyl , cascade reaction , simplicity , component (thermodynamics) , scalability , reaction conditions , organic chemistry , catalysis , database , computer science , philosophy , physics , epistemology , thermodynamics
A multicomponent domino reaction of thiourea, alkyl propiolates, aldehydes, and isocyanides has been established, providing direct access to 2‐aryl‐5 H ‐imidazo[2,1‐ b ][1,3]thiazin‐5‐one scaffolds. The simplicity of execution, readily available substrates, cheap reagents, high yields, excellent functional group tolerance, scalability, and good scores of environmental parameters make this synthetic strategy more efficient and worthy of further attention.