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Synthesis of P‐Stereogenic Tetraphosphacrowns
Author(s) -
Kato Ryosuke,
Morisaki Yasuhiro,
Chujo Yoshiki
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500343
Subject(s) - stereocenter , enantiopure drug , chemistry , boranes , stereochemistry , derivative (finance) , platinum , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , boron , financial economics , economics
Synthetic routes to enantiopure P‐stereogenic tetraphosphacrowns, containing four chiral phosphorus atoms, using a P‐stereogenic secondary bisphosphine are reported. 18‐Tetraphosphacrown‐6 and 24‐tetraphosphacrown‐8 derivatives were prepared by a single‐step and multistep method, respectively, and their characterizations are described in detail. Removal of boranes from the 24‐tetraphosphacrown‐8 derivative and subsequent complexation with platinum(II) are also described.