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Straightforward Synthesis of 2‐Arylquinoxalines from 2‐Nitroanilines with an Equimolar Amount of Monoalcohols via a Base‐Catalyzed Hydrogen‐Transfer Coupling Reaction
Author(s) -
Lv Wan,
Xiong Biao,
Tan Zhenda,
Jiang Huanfeng,
Zhang Min
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500321
Subject(s) - chemistry , catalysis , reagent , combinatorial chemistry , base (topology) , substrate (aquarium) , hydrogen atom , scope (computer science) , coupling reaction , reaction conditions , transition metal , hydrogen , organic chemistry , mathematical analysis , oceanography , alkyl , mathematics , computer science , programming language , geology
Via a base‐catalyzed hydrogen‐transfer coupling reaction, a straightforward synthesis of 2‐arylquinoxalines from readily available 2‐nitroanilines with only an equimolar amount of monoalcohols has been developed. The synthetic protocol proceeds in a step‐ and atom‐economic fashion together with the advantages of operational simplicity, broad substrate scope, water as the only byproduct, and no need for noble transition‐metal catalysts, external reducing agents, or less environmentally benign halogenated reagents, offers a highly practical approach to access 2‐arylquinoxalines.