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Palladium‐Catalysed Direct Arylation using Free‐Amine‐Substituted Polyfluoroanilines with Inhibition of Amination‐Type Reaction
Author(s) -
Takfaoui Abdelilah,
Touzani Rachid,
Soulé JeanFrançois,
Dixneuf Pierre H.,
Doucet Henri
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500268
Subject(s) - amination , palladium , amine gas treating , chemistry , aryl , base (topology) , combinatorial chemistry , reaction conditions , catalysis , organic chemistry , medicinal chemistry , mathematics , mathematical analysis , alkyl
The palladium‐catalysed C−C bond formation via direct arylation of free‐amine‐substituted polyfluoroaniline derivatives proceeds in moderate to high yields with a variety of aryl bromides. The nature of the base was found to be crucial to promote the direct arylation with inhibition of the amination reaction.