Generalized Approach to Asymmetric Synthesis of β‐Substituted β‐Amino Acids Bearing CHF 2 , CBrF 2 , and CClF 2 Groups

Currently, there is a great demand for the development of new methods for the preparation of fluorine containing compounds. However, biologically relevant molecules bearing fluoroalkyl groups other than CF 3 still remain virtually unexplored. Herein, we report a simple approach for preparation of β‐amino acids derivatives containing CHF 2 , CBrF 2 , and CClF 2 groups via addition reactions of the corresponding ( S s)‐ N ‐( tert ‐butanesulfinyl)‐CXF 2 ‐acetaldimines and alkyl‐acetate‐derived enolates. The reactions occur with excellent diastereoselectivity of up to >99:1 providing a simple and reliable access to a type of biologically valuable derivatives.