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Synthesis of Multifunctional Alkenes from Substituted Acrylates and Aldehydes via Phosphine‐Catalyzed Wittig Reaction
Author(s) -
Tsai YiLing,
Lin Wenwei
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500251
Subject(s) - phosphine , wittig reaction , chemistry , phosphine oxide , catalysis , silane , organic chemistry , combinatorial chemistry
An efficient synthesis of multifunctional alkenes starting from substituted acrylates and aldehydes has been developed via phosphine‐catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30–60 °C) via a phosphine/phosphine oxide catalytic cycle using phenyl silane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.