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Copper‐Catalyzed Synthesis of Amino‐Substituted Polycyclic Aromatic Hydrocarbons by the Sequential Reaction between Aryl Alkynyl Carboxylic Acids and Amines
Author(s) -
Choi Jinseop,
Park Kyungho,
Lim Jeongah,
Jung Hyun Min,
Lee Sunwoo
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500227
Subject(s) - chemistry , catalysis , yield (engineering) , aryl , copper , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl , materials science , metallurgy
Abstract Amino‐substituted polycyclic aromatic hydrocarbons were obtained by the reaction between aryl alkynyl carboxylic acids and amines in the presence of a copper catalyst. The hydrocarbons were obtained in good yield without the need to isolate the 1,4‐diaryl‐1,3‐butadiyne intermediate. The best result was obtained using a combination of CuCl and Cu(OTf) 2 , and the reactions of cyclic and acyclic secondary amines afforded the desired products.