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Enantioselective Reduction of Ketones Induced by a C 2 ‐Symmetrical Chiral Hydroxyamide/Titanium(IV) complex
Author(s) -
Phothongkam Supannee,
Uang BiingJiun
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500175
Subject(s) - enantioselective synthesis , chemistry , titanium , ketone , catalysis , chiral auxiliary , organic chemistry , reducing agent , combinatorial chemistry
The asymmetric reduction of ketones catalyzed by chiral titanium complex, prepared in situ from titanium tetraisopropoxide and a C 2 ‐symmetrical chiral hydroxyamide, with catecholborane as the reducing agent afforded the corresponding chiral secondary alcohols in good yields with high enantioselectivity of up to>99 % ee .
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