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Copper‐Catalyzed β‐Selective Hydroborylation of Ynamides: A Facile Access to ( E )‐β‐Alkenylamide Boronates
Author(s) -
Bai Yihui,
Zhang Fang,
Shen Jiajia,
Luo Fang,
Zhu Gangguo
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500119
Subject(s) - chemistry , hydroboration , borylation , regioselectivity , stereoselectivity , reagent , catalysis , combinatorial chemistry , copper , organoboron compounds , organic chemistry , aryl , alkyl
A Cu‐catalyzed, highly β‐selective borylation of ynamides with bis(pinacolato)diboron as the hydroboration reagent is reported, giving ( E )‐β‐alkenylamide boronates in excellent regio‐ and stereoselectivity under mild reaction conditions, which provides a complementary regioselectivity to the existing methods.