Premium
Metal‐Free Direct Aryltrifluoromethylation of Allylic Alcohols with Langlois’ Reagent through Concomitant 1,2‐Aryl Migration
Author(s) -
Huang HongLi,
Yan Hang,
Gao GuoLin,
Yang Chao,
Xia Wujiong
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500096
Subject(s) - allylic rearrangement , chemistry , reagent , aryl , trifluoromethyl , functional group , organic chemistry , metal , cascade , combinatorial chemistry , catalysis , chromatography , alkyl , polymer
A metal‐free and cost‐effective synthetic protocol for selective aryltrifluoromethylation of allylic alcohols with Langlois’ reagent (CF 3 SO 2 Na) through cascade trifluoromethyl radical addition/1,2‐aryl migration has been developed. The highlights of this procedure are operational simplicity, excellent functional group tolerance, and mild reaction conditions.