Metal‐Free Direct Aryltrifluoromethylation of Allylic Alcohols with Langlois’ Reagent through Concomitant 1,2‐Aryl Migration | Zendy

Huang HongLi | Zendy; Yan Hang | Zendy; Gao GuoLin | Zendy; Yang Chao | Zendy; Xia Wujiong | Zendy

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Metal‐Free Direct Aryltrifluoromethylation of Allylic Alcohols with Langlois’ Reagent through Concomitant 1,2‐Aryl Migration

Author(s) -

Huang HongLi,

Yan Hang,

Gao GuoLin,

Yang Chao,

Xia Wujiong

Publication year - 2015

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201500096

Subject(s) - allylic rearrangement , chemistry , reagent , aryl , trifluoromethyl , functional group , organic chemistry , metal , cascade , combinatorial chemistry , catalysis , chromatography , alkyl , polymer

A metal‐free and cost‐effective synthetic protocol for selective aryltrifluoromethylation of allylic alcohols with Langlois’ reagent (CF 3 SO 2 Na) through cascade trifluoromethyl radical addition/1,2‐aryl migration has been developed. The highlights of this procedure are operational simplicity, excellent functional group tolerance, and mild reaction conditions.

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