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Stereocontrolled Synthesis of the C1‐C10 Fragments of Monensin B and Laidlomycin
Author(s) -
Kang Sungkyoung,
Lee Wonchul,
Jung Byunghyuck,
Lee HeeSeung,
Kang Sung Ho
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500078
Subject(s) - chemistry , aldol reaction , monensin , total synthesis , enantioselective synthesis , stereochemistry , block (permutation group theory) , combinatorial chemistry , organic chemistry , catalysis , geometry , mathematics
An efficient synthetic route to the C1‐C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn ‐aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti ‐aldol reaction for C3 and C4, the Tishchenko–Evans reaction for C5, and a chiral building block for C2.
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