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Copper‐Catalyzed Oxidative C−H Amination: Synthesis of Imidazo[1,2‐ a ]‐N‐Heterocycles from N‐Heteroaryl Enaminones
Author(s) -
Reddy K. Ranjith,
Reddy A. Siva,
Shankar Ravi,
Kant Rajni,
Das Parthasarathi
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500052
Subject(s) - chemistry , amination , catalysis , imidazole , oxidative phosphorylation , copper , ligand (biochemistry) , oxidative coupling of methane , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry
A copper(I)‐catalyzed oxidative C−N bond cross‐coupling reactions for the construction of imidazole‐containing nitrogen bridgehead heterocycles have been developed under ligand‐ and base‐free conditions. The open‐air reaction conditions were general and successfully applied in the synthesis of heterocycles, such as substituted imidazo[1,2‐ a ]pyridines, imidazo[1,2‐ a ]pyrimidines, and imidazo[1,2‐ a ]pyrazines.