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Ruthenium as a Single Catalyst for Two Steps: One‐Pot Ruthenium(II)‐Catalyzed Aerobic Oxidative Dehydrogenation of Dihydroquinazolinones and Cross‐Coupling/Annulation to give N‐Fused Polycyclic Heteroarenes
Author(s) -
Lingayya Rajaka,
Vellakkaran Mari,
Nagaiah Kommu,
Nanubolu Jagadeesh Babu
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201500025
Subject(s) - dehydrogenation , chemistry , annulation , ruthenium , catalysis , molecular oxygen , oxidative coupling of methane , combinatorial chemistry , oxidative phosphorylation , coupling (piping) , oxygen , photochemistry , copper , organic chemistry , mechanical engineering , biochemistry , engineering
One single catalyst, [RuCl 2 ( p ‐cymene)] 2 , was used for oxidative dehydrogenation followed by cross‐coupling/annulation reactions to access diversely decorated N‐fused polycyclic heteroarenes from dihydroquinazolinones and alkynes. This one‐pot method does not require purification of intermediates or addition of copper salts. The synergistic use of molecular oxygen as the oxidant highlights the sustainable aspect of this method.