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Cover Picture: Direct Assembly of Benzo[ a ]carbazole‐5‐carboxylates via a Diels–Alder Reaction with Arynes and 3‐Alkenylindoles (Asian J. Org. Chem. 12/2014)
Author(s) -
Tao Yuan,
Zhang Fei,
Tang ChenYu,
Wu XinYan,
Sha Feng
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201490025
Subject(s) - aryne , carbazole , chemistry , diels–alder reaction , yield (engineering) , cycloaddition , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , materials science , metallurgy
Benzo[ a ]carbazole and its derivatives are a class of important compounds due to their significant biological properties and wide utilization as antitumor agents in pharmaceutical chemistry. In their Full Paper on page 1292 ff., Feng Sha and co‐workers have developed a one‐step synthetic approach to benzo[ a ]carbazoles via the Diels‐Alder reaction of arynes and 3‐alkenylindoles. The reaction has a broad substrate scope and 40 benzo[ a ]carbazole compounds were furnished in up to 99% yield. Also, this method affords benzo[ a ]carbazoles with free NH bonds directly in a transition‐metal‐free manner.