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Cover Picture: Substituent Enabled Divergent Synthesis of N‐Heterocycles: a Metal Carbene Approach Involving Intramolecular Carbene Interception (Asian J. Org. Chem. 11/2014)
Author(s) -
Xu HuaDong,
Xu Ke,
Jia ZhiHong,
Zhou Hao,
Jiang Pan,
Lu XiaoLong,
Pan YingPeng,
Wu Hao,
Ding Yun,
Shen MeiHua,
Pan XianHua
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201490023
Subject(s) - carbene , chemistry , substituent , intramolecular force , aldehyde , aryl , alkoxy group , medicinal chemistry , stereochemistry , catalysis , organic chemistry , alkyl
Divergent synthesis of two value‐added N‐heterocycles bearing a versatile aldehyde group is accomplished in a one‐pot operation. In their Communication on page 1154 ff., Hua‐Dong Xu, Mei‐Hua Shen and co‐workers report that N‐aryl‐N‐allyl‐bis‐functionalized amino‐1‐sulfonyl‐1,2,3‐triazoles undergo Rh‐catalyzed cyclization reactions and subsequent hydrolysis to give two distinct N‐heterocyclic structures, 3‐indolyl aldehydes and 3‐azabicyclo[3,1,0]hexyl aldehydes. The product ratio can be tuned by varying the electronic properties of the two carbene receptors attached to the N atom. Image designed by H. Xu and produced by Changjiang Ma.