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Ion‐Pair‐Catalyzed Sodium Borohydride Reduction in Aprotic Organic Solvents
Author(s) -
Ning XiaoShan,
Dong XueJiao,
Xiao ZuFeng,
Yao ChuanZhi,
Kang YanBiao
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402281
Subject(s) - chemistry , sodium borohydride , catalysis , methanol , stoichiometry , borohydride , solvent , inorganic chemistry , sodium , ammonium , organic chemistry
Sodium borohydride reduction in aprotic solvents has always been an unsolved problem. In this work a ion‐pair‐catalyzed sodium borohydride reduction in aprotic solvents was kinetically and mechanistically studied. Finally sodium borohydride reduction could be carried out in common aprotic solvents efficiently under mild conditions. A large quantity of water or methanol as the solvent or co‐solvent has been avoided. The generation of stoichiometric or excess organic ammonium waste has also been avoided. The normal acidic work‐up is not necessary and the catalyst was recycled.