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One‐Pot Synthesis of 2‐Arylbenzoxazoles by Gas‐Free Carbonylation using Dicobalt Octacarbonyl as a Solid Carbon Monoxide Source
Author(s) -
Baburajan Poongavanam,
Elango Kuppanagounder P.
Publication year - 2015
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402252
Subject(s) - carbonylation , chemistry , chemoselectivity , carbon monoxide , aryl , catalysis , yield (engineering) , monoxide , combinatorial chemistry , organic chemistry , photochemistry , alkyl , materials science , metallurgy
A simple, mild, and facile carbonylation procedure to synthesise 2‐arylbenzoxazole derivatives using dicobalt octacarbonyl [Co 2 (CO) 8 ] as an in situ carbon monoxide source is described. This method is tolerant of a variety of functional groups and the compounds are obtained in high to excellent yields. Moreover, the reaction is performed in one‐pot with a simple workup procedure. The choice of catalytic system as well as base is important in order to ensure a high yield and chemoselectivity in the reaction. Both electron‐rich and electron‐deficient aryl bromides worked well in this reaction.