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Efficient Copper Catalyzed CN Coupling Reaction in Water by Using 2‐Hydroxybenzohydrazides as Ligands
Author(s) -
Yan NanNan,
Wu FengTian,
Zhang Jie,
Wei QianBing,
Liu Ping,
Xie JianWei,
Dai Bin
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402136
Subject(s) - chemistry , halide , nucleophile , catalysis , aryl , ligand (biochemistry) , environmentally friendly , copper , combinatorial chemistry , nitrogen , coupling reaction , organic chemistry , ecology , biochemistry , alkyl , receptor , biology
An efficient and environmentally friendly protocol has been developed for CuSO 4 ‐catalyzed N ‐arylation of nitrogen‐containing nucleophiles with aryl halides in water. The method uses 2‐hydroxybenzohydrazides as ligand, avoids the use of organic solvents, and tolerates functional groups well.