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Mother Diamine: A Universal Building Block for Making Chiral Ligands from Daughter Diamines to Binol, Binap and Monophos Analogues
Author(s) -
Lee Ansoo,
So Soon Mog,
Lough Alan J.,
Kim Hyunwoo,
Chin Jik
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402135
Subject(s) - chemistry , binap , ethylenediamine , diamine , vicinal , stereoselectivity , enantioselective synthesis , reactivity (psychology) , stereochemistry , catalysis , medicinal chemistry , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology
“Mother diamine” (MD) or 1,2‐bis(2‐hydroxy‐phenyl)ethylenediamine can be rapidly transformed to a wide variety of chiral ligands including vicinal diamines and analogs of binol (MDdiol), binap (MDdiphos), and monophos (MDphos). The reactivity and stereoselectivity of the MDphos ligands in Rh‐catalyzed hydrogenation are highly sensitive to the N,N ′‐dialkyl substituents.