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Synthetic Studies Toward Harringtonolide
Author(s) -
Ma Zhiqiang,
Cheng Bin,
Zhai Hongbin
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402116
Subject(s) - chemistry , cycloaddition , bicyclic molecule , combinatorial chemistry , reaction conditions , stereochemistry , organic chemistry , catalysis
An efficient synthesis of an oxo‐bridged 7/6‐bicyclic precursor that is potentially useful for the construction of harringtonolide has been realized through a [4+3] cycloaddition reaction. Meanwhile, an unexpected rearrangement reaction, which could be used for the fast assembly of spirocycles, was found during the double elimination attempts.