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Alkylideneindoleninium Ions and Alkylideneindolenines: Key Intermediates for the Asymmetric Synthesis of 3‐Indolyl Derivatives
Author(s) -
Wang Liang,
Chen Yuye,
Xiao Jian
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402093
Subject(s) - chemistry , nucleophile , combinatorial chemistry , reagent , ion , enantioselective synthesis , organic chemistry , catalysis
Alkylideneindoleninium ions and alkylideneindolenines generated from 3‐substituted indoles are important intermediates in organic synthesis, which can be trapped by a large variety of nucleophilic reagents to construct biologically important 3‐indolyl derivatives. This Focus Review summarizes the recent developments in asymmetric syntheses of 3‐indolyl derivatives via alkylideneindoleninium ions or alkylideneindolenines. The elimination mechanism of leaving groups and asymmetric strategies are discussed.