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Decarboxylative CP Coupling of o ‐Nitrobenzoic Acids with H‐Phosphonates
Author(s) -
Li Junchen,
Bi Xiaojing,
Wang Hongmei,
Xiao Junhua
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402088
Subject(s) - chemistry , bimetallic strip , aryl , palladium , catalysis , medicinal chemistry , ring (chemistry) , decarboxylation , inert , benzoic acid , combinatorial chemistry , stereochemistry , organic chemistry , alkyl
We describe a decarboxylative CP coupling of o ‐nitrobenzoic acids with H‐phosphonates by using a bimetallic palladium/silver catalytic system. Many common functional groups on the phenyl ring of o ‐nitrobenzoic acids, such as MeO, NO 2 , F, Cl, and Br, are well tolerated under these conditions. Nevertheless, m ‐ or p ‐substituted benzoic acids are inert for the reaction. This transformation provides an approach to biologically and synthetically important aryl phosphonates.