Design of Peptidyl Thiourea Derivatives as Organocatalysts for the Asymmetric Ring Opening of  meso ‐Stilbene Oxides | Zendy

Chimni Swapandeep Singh | Zendy; Kumar Vikas | Zendy; Bala Neeraj | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Design of Peptidyl Thiourea Derivatives as Organocatalysts for the Asymmetric Ring Opening of meso ‐Stilbene Oxides

Author(s) -

Chimni Swapandeep Singh,

Kumar Vikas,

Bala Neeraj

Publication year - 2014

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201402040

Subject(s) - chemistry , thiourea , stereocenter , organocatalysis , ring (chemistry) , enantioselective synthesis , stereochemistry , residue (chemistry) , catalysis , organic chemistry , combinatorial chemistry

Chiral peptidyl thiourea organocatalysts were designed and synthesized for asymmetric ring‐opening of cis ‐stilbene oxides with N ‐phenylpiperazines. Chiral β ‐amino alcohols were obtained with up to 95 % ee after crystallization. The configuration at the N‐terminal residue stereogenic center of peptidyl thiourea organocatalyst was found to affect the stereochemical outcome of the reaction.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research