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Recent Advances in the Synthesis of Carbocyclic Nucleosides via Ring‐Closing Metathesis
Author(s) -
Mulamoottil Varughese A.,
Nayak Akshata,
Jeong Lak Shin
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402032
Subject(s) - chemistry , ring closing metathesis , combinatorial chemistry , metathesis , catalysis , enantioselective synthesis , salt metathesis reaction , olefin metathesis , nucleoside , nanotechnology , stereochemistry , organic chemistry , polymerization , polymer , materials science
The past decades witnessed the development and the strong potential of nucleoside analogues as therapeutic agents as well as biological tools. Among this, five‐membered carbocyclic nucleosides have shown immense promise in the treatment of cancer and viral infections. The systematic evolution of transition‐metal‐catalyzed CC bond‐forming reactions has widened the scope of olefin metathesis. The development of new catalysts, the selectivity, efficiency, functional‐group compatibility, along with a better know‐how of the catalyst–substrate interactions have encouraged researchers to use this powerful tool for the design of desired target compounds. The aim of this Focus Review is to highlight recently developed synthetic strategies for the synthesis of carbocyclic nucleosides involving ring‐closing metathesis (RCM) as a key step.