Remarkable Enhancement of the Rate of the Intramolecular Morita–Baylis–Hillman Reaction by the Combination of a Nucleophilic Catalyst and 1,3‐Diphenyl‐2‐thiourea | Zendy

Mandai Hiroki | Zendy; Shimowaki Keita | Zendy; Mitsudo Koichi | Zendy; Suga Seiji | Zendy

Premium

Remarkable Enhancement of the Rate of the Intramolecular Morita–Baylis–Hillman Reaction by the Combination of a Nucleophilic Catalyst and 1,3‐Diphenyl‐2‐thiourea

Author(s) -

Mandai Hiroki,

Shimowaki Keita,

Mitsudo Koichi,

Suga Seiji

Publication year - 2014

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201402001

Subject(s) - chemistry , thiourea , intramolecular force , nucleophile , catalysis , medicinal chemistry , adduct , baylis–hillman reaction , organic chemistry

The rate of the intramolecular Morita‐Baylis–Hillman (MBH) reaction is remarkably enhanced by the combination of catalytic amounts of a nucleophilic catalyst (4‐dimethylaminopyridine (DMAP), 4‐pyrrolidinopyridine (PPY), or PBu 3 ) and 1,3‐diphenyl‐2‐thiourea, and the desired MBH adducts are obtained in good to high yields within a few hours.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research