Premium
Remarkable Enhancement of the Rate of the Intramolecular Morita–Baylis–Hillman Reaction by the Combination of a Nucleophilic Catalyst and 1,3‐Diphenyl‐2‐thiourea
Author(s) -
Mandai Hiroki,
Shimowaki Keita,
Mitsudo Koichi,
Suga Seiji
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201402001
Subject(s) - chemistry , thiourea , intramolecular force , nucleophile , catalysis , medicinal chemistry , adduct , baylis–hillman reaction , organic chemistry
Abstract The rate of the intramolecular Morita‐Baylis–Hillman (MBH) reaction is remarkably enhanced by the combination of catalytic amounts of a nucleophilic catalyst (4‐dimethylaminopyridine (DMAP), 4‐pyrrolidinopyridine (PPY), or PBu 3 ) and 1,3‐diphenyl‐2‐thiourea, and the desired MBH adducts are obtained in good to high yields within a few hours.