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N 1 ‐Selective Oxidative CN Coupling of Azoles with Pyrroles Using a Hypervalent Iodine Reagent
Author(s) -
Morimoto Koji,
Ohnishi Yusuke,
Nakamura Akira,
Sakamoto Kazuma,
Dohi Toshifumi,
Kita Yasuyuki
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201400027
Subject(s) - hypervalent molecule , chemistry , reagent , iodine , oxidative coupling of methane , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis
A method for coupling azoles with pyrroles and related compounds using a hypervalent iodine reagent has been developed. The oxidative coupling to produce the CN bond directly from CH and NH bonds is attractive in view of sustainable chemistry by avoiding prefunctionalization of the substrates. Notably, the reactions are found to be N 1 ‐selective at the azoles and tolerant of a broad range of substrates and functional groups.