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Organocatalytic Asymmetric Condensation/Keto–Enol Tautomerization Tandem Reaction: Access to Cyclobutanone α‐Amino Acid Ester Derivatives
Author(s) -
Frongia Angelo,
Melis Nicola,
Serra Ilaria,
Secci Francesco,
Piras Pier Paolo,
Caboni Pierluigi
Publication year - 2014
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201400020
Subject(s) - chemistry , tautomer , enol , optically active , cyclobutanone , amino acid , tandem , cascade reaction , enantioselective synthesis , condensation , organic chemistry , alkyl , condensation reaction , organocatalysis , catalysis , combinatorial chemistry , ring (chemistry) , biochemistry , materials science , physics , composite material , thermodynamics
A practical method for the synthesis of optically active α‐amino cyclobutanones has been developed, via an organocatalytic asymmetric condensation reaction between racemic 2‐hydroxycyclobutanone and chiral N ‐alkyl‐α‐amino acid ester derivatives.